Low-temperature thermoplastics have been used in human rehabilitative medicine for custom splinting since the 1960s. The versatility of thermoplastics enables them to be shaped to any body part, and used for creating custom designs to meet various patient needs (Figures 1 and 2). Splints are fabricated to target a variety of conditions and goals: To stabilize or immobilize a body part (e.g., fracture management), protect against injury (e.g., from neglect following cerebral vascular accident), prevent injury of healing structures (e.g., following tendon repair), and prevent or correct deformity (e.g., ulnar deviation from rheumatoid arthritis).